Back to search

Article

Maternal Immune Activation with High Molecular Weight Poly (I:C) Induces Selective Depressive-Like Phenotype in Adult Offspring

2025-07-23

Abstract excerpt

<title>Abstract</title> <p> Maternal immune activation (MIA) during pregnancy may increase the risk for neurodevelopmental disorders such as schizophrenia and autism in offspring. Preclinical and human evidence support a potential role for MIA in the development of depressive symptoms in offspring. Among animal models of MIA, prenatal treatment with the synthetic viral mimetic polyinosinic-polycytidylic acid [po...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
d684eb61-38eb-5078-96e6-129590cf2e03
DOI
10.21203/rs.3.rs-7131610/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Maternal Immune Activation with High Molecular Weight Poly (I:C) Induces Selective Depressive-Like Phenotype in Adult OffspringDOI 10.21203/rs.3.rs-7131610/v1
Maternal immune activation with high molecular weight poly (I:C) induces selective depressive-like phenotype in adult offspring.Semantic proximity
Paternal high molecular weight poly I:C administration alters the sperm small non-coding RNA profile and offspring brain development and behavioural phenotype.Semantic proximity
Repeated intermittent administration of (R)-ketamine during juvenile and adolescent stages prevents schizophrenia-relevant phenotypes in adult offspring after maternal immune activation: a role of TrkB signaling.Semantic proximity
Vitamin D treatment during pregnancy prevents autism-related phenotypes in a mouse model of maternal immune activation.Semantic proximity
Impact of Maternal Immune Activation Early in Pregnancy on Brain Development of Offspring: A Combined Morphological, Spectroscopic, and Behavioral StudySemantic proximity
Interaction between maternal immune activation and postpartum immune stress in neuropsychiatric phenotypes.Semantic proximity
LPS versus Poly I:C model: comparison of long-term effects of bacterial and viral maternal immune activation on the offspringSemantic proximity
A temporal map of maternal immune activation-induced changes reveals a shift in neurodevelopmental timing and perturbed cortical development in miceSemantic proximity
Alterations in retrotransposition, synaptic connectivity, and myelination implicated by transcriptomic changes following maternal immune activation in non-human primatesSemantic proximity
Induction of Toll-Like Receptor 3-Mediated Immunity during Gestation Inhibits Cortical Neurogenesis and Causes Behavioral DisturbancesSemantic proximity
Maternal Immune Activation Disrupts Dopamine System in the OffspringSemantic proximity
Advancing Autism Research From Mice to Marmosets: Behavioral Development of Offspring Following Prenatal Maternal Immune ActivationSemantic proximity
Select a neighboring publication to make it the new centre.