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APOE4 Genotype is Associated with Reduced Cortical VEGFR2 ( <i>KDR</i> ) Transcript Levels Independent of Endothelial Abundance: An AMP-AD RNA-seq Pilot Study

2026-03-03

Abstract excerpt

<h4>Background</h4> Apolipoprotein E4 ( APOE4 ) is the strongest common genetic risk factor for late-onset Alzheimer’s disease and has been implicated in cerebrovascular dysfunction. Vascular endothelial growth factor receptor 2 (VEGFR2), encoded by the gene KDR , is a key regulator of endothelial integrity and blood-brain barrier (BBB) maintenance; however, its relationship to APOE4 status in human brain tissu...

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Literature Corpus work
7960c766-8465-5fc6-9f25-76ff6238d154
DOI
10.64898/2026.03.01.708815
Open publication

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APOE4 Genotype is Associated with Reduced Cortical VEGFR2 ( <i>KDR</i> ) Transcript Levels Independent of Endothelial Abundance: An AMP-AD RNA-seq Pilot StudyDOI 10.64898/2026.03.01.708815
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