Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Causal Effects of the Plasma Proteome on Vascular Dementia Risk: A Mendelian Randomization Study with Experimental Validation

7 Jul 2025

Abstract excerpt

Vascular dementia (VaD) is a prevalent form of dementia caused by cerebrovascular disease, leading to cognitive impairment. While various risk factors have been identified, the role of plasma proteins in VaD etiology remains poorly understood. This study employs Mendelian randomization (MR) to investigate the causal relationship between plasma proteins and VaD risk, complemented by experimental validation. We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Associations and Epidemiology
Share to Nutritional Studies and Diet
Share to Regulation of Appetite and Obesity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40622612
DOI: 10.1007/s10571-025-01583-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Causal Effects of the Plasma Proteome on Vascular Dementia Risk: A Mendelian Randomization Study with Experimental ValidationPMID 40622612Read ↗

Causes and consequences of vascular dementia across the life course: Evidence from a UK Biobank phenome-wide and Mendelian randomization studySemantic proximity Read ↗

Proteomic profiling of Alzheimer’s disease and Vascular dementia reveals unique underlying signaturesSemantic proximity Read ↗

Exploring the bidirectional relationships between alzheimer's disease and cerebral small vessel disease: Insights from mendelian randomizationSemantic proximity Read ↗

Proteogenomics in cerebrospinal fluid and plasma reveals new biological fingerprint of cerebral small vessel diseaseSemantic proximity Read ↗

A foundation model for mapping the phenomic and genetic landscape of cerebral small vessel disease biomarkersSemantic proximity Read ↗

Causal association between blood leukocyte counts and vascular dementia: a two-sample bidirectional Mendelian randomization study.Semantic proximity Read ↗

A genome-wide association meta-analysis of all-cause and vascular dementia.Semantic proximity Read ↗

Causal Effect of Multi-cohort Circulating Proteome on the Risk of Aortic Aneurysm: A Mendelian Randomization StudySemantic proximity Read ↗

A meta-analysis of genome-wide association studies identifies new genetic loci associated with all-cause and vascular dementiaSemantic proximity Read ↗

Plasma Proteomics and Sensitive Imaging Biomarkers of Vascular Brain InjurySemantic proximity Read ↗

Deciphering causal proteins in Alzheimer’s disease: A novel Mendelian randomization method integrated with AlphaFold3 for 3D structure predictionSemantic proximity Read ↗

Systematic evaluation of multifactorial causal associations for Alzheimer's disease and an interactive platform based on Mendelian randomization analysis——MRADSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.