Article
Stearoyl-CoA desaturase inhibition normalizes brain lipid saturation, α-synuclein homeostasis, and motor function in mutant Gba1-Parkinson mice.
JCI insight - 8 Jul 2025
Nuber Silke, Hsiang Harrison, Keewan Esra'a, Moors Tim E, Reitz Sydney J, Tiwari Anupama, Ho Gary Ph, Su Elena, Hahn Wolf, Adom Marie-Alexandre, Pathak Riddhima, Blizzard Matthew, Kim Sangjune, Ko Han Seok, Zhang Xiaoqun, Svenningsson Per, Selkoe Dennis J, Fanning Saranna
Abstract excerpt
Loss-of-function mutations in the GBA1 gene are a prevalent risk factor for Parkinson's disease (PD). Defining features are Lewy bodies that can be rich in α-synuclein (αS), vesicle membranes, and other lipid membranes, coupled with striatal dopamine loss and progressive motor dysfunction. Of these, lipid abnormalities are the least understood. An altered lipid metabolism in PD patient-derived neurons - carrying...
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- Animals
- Stearoyl-CoA Desaturase
- alpha-Synuclein
- Mice
- Glucosylceramidase