Article

Restriction of individual branched-chain amino acids has distinct effects on the development and progression of Alzheimer’s disease in 3xTg mice

2025-07-26

Abstract excerpt

Dietary protein is a critical regulator of metabolic health and aging in diverse species. Recent discoveries have determined that many benefits of a low protein diet are the result of reduced consumption of the three branched-chain amino acids (BCAAs), leucine, isoleucine, and valine. Intriguingly, each BCAA has distinct physiological and molecular effects, with restriction of isoleucine alone being sufficient to...

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Literature Corpus work: 83cc0ac3-c091-5539-918a-6485b4c650f1
DOI: 10.1101/2025.07.24.663565

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