Article

RepliCNN: High-resolution inference of the DNA replication program from strand-specific 3′ DNA end sequencing

2026-03-14

Abstract excerpt

During S phase, the genome is replicated in a tightly regulated spatiotemporal order described as DNA replication timing (RT). Discontinuous lagging-strand synthesis produces Okazaki fragments whose strand-specific distribution reflects replication dynamics. Here, we present RepliCNN, a deep learning framework based on one-dimensional convolutional neural networks to predict RT from Okazaki fragment distributions...

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Literature Corpus work: 79364c63-97ed-556c-a78f-b9c046097313
DOI: 10.64898/2026.03.12.710907

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