Article

Analysis of factor V in zebrafish demonstrates minimal levels needed for hemostasis and risk stratifies human variants

2019-03-05

Abstract excerpt

<h4>ABSTRACT</h4> In humans, coagulation factor V (F5) deficiency is a rare, clinically heterogeneous bleeding disorder, suggesting that genetic modifiers may contribute to disease expressivity. Complete loss of mouse F5 results in early lethality. Zebrafish possess many distinct advantages including high fecundity, optical clarity, external development, and homology with the mammalian hemostatic system, features...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 79333fa8-2d2b-51a2-9fb5-d1d14cc14c77
DOI: 10.1101/567453

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Analysis of factor V in zebrafish demonstrates minimal levels needed for hemostasis and risk stratifies human variantsDOI 10.1101/567453Read

Analysis of factor V in zebrafish demonstrates minimal levels needed for early hemostasisSemantic proximity Read

Genome editing of factor X in zebrafish reveals unexpected tolerance of severe defects in the common pathway.Semantic proximity Read

Characterization of zebrafish coagulation cofactors Fviii and Fv mutants and modeling hemophilia A and factor V deficiency.Semantic proximity Read

Zebrafish as a model system for the study of hemostasis and thrombosisSemantic proximity Read

Effect of a truncated mutant factor V on hemostatic function and embryonic development in mice.Semantic proximity Read

Disruption of the kringle 1 domain of prothrombin leads to late onset mortality in zebrafishSemantic proximity Read

A sensitized model of thrombosis validates known multigenic relationships and suggests novel modifiers of hemostasisSemantic proximity Read

Loss of fibrinogen in zebrafish results in symptoms consistent with human hypofibrinogenemia.Semantic proximity Read

Factor V deficiency.Semantic proximity Read

Loss of factor VIII in zebrafish rebalances antithrombin deficiency but has a limited bleeding diathesisSemantic proximity Read

Loss of factor VIII in zebrafish rebalances antithrombin deficiency but has a limited bleeding diathesisSemantic proximity Read

A sensitized mutagenesis screen in Factor V Leiden mice identifies novel thrombosis suppressor lociSemantic proximity Read