Article

Disruption of the kringle 1 domain of prothrombin leads to late onset mortality in zebrafish

2019-03-14

Abstract excerpt

The ability to prevent blood loss in response to injury is a critical, evolutionarily conserved function of all vertebrates. Prothrombin (F2) contributes to both primary and secondary hemostasis through the activation of platelets and the conversion of soluble fibrinogen to insoluble fibrin, respectively. Complete prothrombin deficiency has never been observed in humans and is incompatible with life in mice, limit...

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Literature Corpus work: 8aa23974-8e0d-5aff-af79-1e2a97228d6f
DOI: 10.1101/576140

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