Back to search

Article

A sensitized model of thrombosis validates known multigenic relationships and suggests novel modifiers of hemostasis

2026-05-13

Abstract excerpt

<h4>Background</h4> Venous thromboembolism is a major cause of morbidity and mortality. Despite identification of risk factors, not all individuals with thrombophilia develop thrombosis. Understanding the multigenic factors modifying this incomplete penetrance would help guide patient care. <h4>Methods</h4> The zebrafish has a conserved hemostatic system and is amenable to large genetic studies. Loss of antithro...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
fc4578a5-e045-5dd1-bcf7-d123a48e79e6
DOI
10.64898/2026.05.11.724445
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A sensitized model of thrombosis validates known multigenic relationships and suggests novel modifiers of hemostasisDOI 10.64898/2026.05.11.724445
Targeted mutagenesis of zebrafish antithrombin III triggers disseminated intravascular coagulation and thrombosis, revealing insight into functionSemantic proximity
Multi-ancestry GWAS for venous thromboembolism identifies novel loci followed by experimental validation in zebrafishSemantic proximity
Zebrafish as a model system for the study of hemostasis and thrombosisSemantic proximity
A sensitized mutagenesis screen in Factor V Leiden mice identifies novel thrombosis suppressor lociSemantic proximity
Multipopulation GWAS for venous thromboembolism identifies novel loci followed by experimental validation in zebrafish.Semantic proximity
Loss of factor VIII in zebrafish rebalances antithrombin deficiency but has a limited bleeding diathesisSemantic proximity
Loss of factor VIII in zebrafish rebalances antithrombin deficiency but has a limited bleeding diathesisSemantic proximity
Characterization of zebrafish coagulation cofactors Fviii and Fv mutants and modeling hemophilia A and factor V deficiency.Semantic proximity
Sensitized mutagenesis screen in Factor V Leiden mice identifies thrombosis suppressor lociSemantic proximity
Zebrafish: a genetic model for hemostasis and thrombosis.Semantic proximity
Analysis of factor V in zebrafish demonstrates minimal levels needed for early hemostasisSemantic proximity
Analysis of factor V in zebrafish demonstrates minimal levels needed for hemostasis and risk stratifies human variantsSemantic proximity
Select a neighboring publication to make it the new centre.