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Loss of factor VIII in zebrafish rebalances antithrombin deficiency but has a limited bleeding diathesis

14 Mar 2025

Abstract excerpt

ABSTRACT: Deficiencies in coagulation factor VIII (FVIII, F8) result in the bleeding disorder hemophilia A. An emerging novel therapeutic strategy for bleeding disorders is to enhance hemostasis by limiting natural anticoagulants, such as antithrombin (AT3). To study pro/anticoagulant hemostatic balance in an in vivo model, we used genome editing to create null alleles for f8 and von Willebrand factor (vwf) in...

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PMID: 40085950
DOI: 10.1182/bloodadvances.2024013143

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