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Analysis of factor V in zebrafish demonstrates minimal levels needed for early hemostasis

5 Jun 2019

Abstract excerpt

Abstract In humans, coagulation factor V (FV) deficiency is a rare, clinically heterogeneous bleeding disorder, suggesting that genetic modifiers may contribute to disease expressivity. Zebrafish possess many distinct advantages including high fecundity, optical clarity, external development, and homology with the mammalian hemostatic system, features that make it ideal for genetic studies. Our aim was to study...

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Share to Blood Coagulation and Thrombosis Mechanisms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 31167819
DOI: 10.1182/bloodadvances.2018029066

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