Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of zebrafish coagulation cofactors Fviii and Fv mutants and modeling hemophilia A and factor V deficiency.

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis - 1 Jul 2024

Dhinoja Sanchi, De Maria Anthony, Qaryoute Ayah Al, Jagadeeswaran Pudur

Abstract excerpt

The aim of this study is to characterize zebrafish coagulation cofactors fviii and fv mutant fish and assess if they phenocopy classical hemophilia A and factor V deficiency in humans. The embryos from fviii and fv zebrafish heterozygote mutants generated by ENU mutagenesis were purchased from the ZIRC repository. They were reared to adulthood and genotyped. The heterozygote male and female were crossed to get...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Coagulation
Share to Disease Models, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Factor V

Share to Factor V Deficiency

Share to Factor VIII

Share to Hemophilia A

Share to Mutation

Share to Zebrafish

Source

Open in PubMed Open full text

Identifiers

PMID: 38874909
DOI: 10.1097/MBC.0000000000001308
PMCID: PMC11230853

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of zebrafish coagulation cofactors Fviii and Fv mutants and modeling hemophilia A and factor V deficiency.PMID 38874909Read ↗

Loss of factor VIII in zebrafish rebalances antithrombin deficiency but has a limited bleeding diathesisSemantic proximity Read ↗

Loss of factor VIII in zebrafish rebalances antithrombin deficiency but has a limited bleeding diathesisSemantic proximity Read ↗

CRISPR/Cas9 mediated generation of zebrafish f9a mutant as a model for hemophilia B.Semantic proximity Read ↗

Analysis of factor V in zebrafish demonstrates minimal levels needed for early hemostasisSemantic proximity Read ↗

Genome editing of factor X in zebrafish reveals unexpected tolerance of severe defects in the common pathway.Semantic proximity Read ↗

Analysis of factor V in zebrafish demonstrates minimal levels needed for hemostasis and risk stratifies human variantsSemantic proximity Read ↗

Zebrafish as a model system for the study of hemostasis and thrombosisSemantic proximity Read ↗

A sensitized model of thrombosis validates known multigenic relationships and suggests novel modifiers of hemostasisSemantic proximity Read ↗

Disruption of the kringle 1 domain of prothrombin leads to late onset mortality in zebrafish.Semantic proximity Read ↗

Disruption of the kringle 1 domain of prothrombin leads to late onset mortality in zebrafishSemantic proximity Read ↗

Loss of fibrinogen in zebrafish results in symptoms consistent with human hypofibrinogenemia.Semantic proximity Read ↗

Haemostatic screening and identification of zebrafish mutants with coagulation pathway defects: an approach to identifying novel haemostatic genes in man.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.