Article
Effect of a truncated mutant factor V on hemostatic function and embryonic development in mice.
Scientific reports - 12 Feb 2026
Miguel-Batuecas Andrea, De Pablo-Moreno Juan A, Porras Néstor, Bermejo-Álvarez Pablo, González-Brusi Leopoldo, Serrano Luis J, De Pablo-Moreno Javier M, Sánchez María José, García-Arranz Mariano, Rodríguez-Bertos Antonio, Chumappumkal Joseph Bilgimol, Revuelta Luis, Liras Antonio
Abstract excerpt
Factor V is an essential protein in the blood clotting process and plays a central role in secondary hemostasis. Its deficiency causes a rare inherited disorder characterized by episodes of severe bleeding, some of which can be life-threatening. Although previous studies have established that factor V is essential for normal embryonic development, its specific contribution to vascular maturation remains...
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