Article

Loss of factor VIII in zebrafish rebalances antithrombin deficiency but has a limited bleeding diathesis

2024-03-03

Abstract excerpt

Deficiencies in coagulation factor VIII (FVIII, F8) result in the bleeding disorder hemophilia A. An emerging novel therapeutic strategy for bleeding disorders is to enhance hemostasis by limiting natural anticoagulants, such as antithrombin (AT3). To study pro/anticoagulant hemostatic balance in an in vivo model, we used genome editing to create null alleles for f8 and von Willebrand factor (vwf) in zebrafish, a...

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Literature Corpus work: 66a5b836-67c7-582f-9783-777ad9fcaa39
DOI: 10.1101/2024.02.28.582609

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