Article
Loss of fibrinogen in zebrafish results in symptoms consistent with human hypofibrinogenemia.
PloS one - 1 Jan 2013
Vo Andy H, Swaroop Alok, Liu Yang, Norris Zachary G, Shavit Jordan A
Abstract excerpt
Cessation of bleeding after trauma is a necessary evolutionary vertebrate adaption for survival. One of the major pathways regulating response to hemorrhage is the coagulation cascade, which ends with the cleavage of fibrinogen to form a stable clot. Patients with low or absent fibrinogen are at risk for bleeding. While much detailed information is known about fibrinogen regulation and function through studies of...
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