Back to search

Article

New MicroRNAs Candidates to Treat Human Colorectal Cancer; Molecular Dynamic Simulations Found a Major Down-Regulator of CLCA4 Tumor Suppressor Gene

2021-04-14

Abstract excerpt

<h4>Introduction: </h4> Colorectal cancer (CRC) is one of the most common malignancies worldwide. The expression of CLCA4 , a tumor suppressor gene, decreases significantly in cancer cells of CRC. In this study, we identified miRNAs target the mRNA of the CLCA4 gene. ObjectiveThe aim of this study was the identification of miRNAs involved in CRC.Material and methodsWe predicted miRNA(s) that target CLCA4 mRNA appl...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
7911e4f3-0225-5507-abef-182b0450d6cc
DOI
10.21203/rs.3.rs-381601/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
New MicroRNAs&nbsp;Candidates to Treat Human Colorectal Cancer; Molecular Dynamic Simulations Found a Major Down-Regulator of CLCA4&nbsp;Tumor Suppressor GeneDOI 10.21203/rs.3.rs-381601/v1
Computational Analysis of crRNA to Regulate hsa-miR-301b-3p and hsa-miR-21 related to metastasis and cell proliferation in acute myeloid leukemia (AML) using CRISPR/C2c2Semantic proximity
Evidence of colorectal cancer risk associated variant Lys25Ser in the proximity of human bone morphogenetic protein 2.Semantic proximity
Role of EFNA1 SNP (rs12904) in Tumorigenesis and Metastasis of Colorectal Cancer: A Bioinformatic Analysis and HRM SNP Genotyping Verification.Semantic proximity
Targeted inhibition of colorectal carcinoma using a designed CEA-binding protein to deliver TCF/LEF transcription factor decoy DNA and p53 proteinSemantic proximity
Predictive role of microRNA-related genetic polymorphisms in the pathological complete response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer patients.Semantic proximity
Impact of microRNA-375 and its target gene SMAD-7 polymorphism on susceptibility of colorectal cancer.Semantic proximity
Screening and computational analysis of colorectal associated non-synonymous polymorphism in CTNNB1 gene in Pakistani population.Semantic proximity
<i>In silico</i> study predicts a key role of RNA-binding domains 3 and 4 in nucleolin-miRNA interactionsSemantic proximity
Computational screening and analysis of deleterious nsSNPs in human p14ARF (CDKN2A gene) protein using molecular dynamic simulation approach.Semantic proximity
Fully Complementary Interactions of Human mRNA Genes with miRNAsSemantic proximity
Direct binding of microRNA-21 pre-element with Regorafenib: An alternative mechanism for anti-colorectal cancer chemotherapy?Semantic proximity
The effect of R249S carcinogenic and H168R-R249S suppressor mutations on p53-DNA interaction, a multi scale computational study.Semantic proximity
Select a neighboring publication to make it the new centre.