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Article

Computational screening and analysis of deleterious nsSNPs in human p14ARF (CDKN2A gene) protein using molecular dynamic simulation approach.

Journal of biomolecular structure & dynamics - 1 Jun 2023

Ahmad Syed Umair, Ali Yasir, Jan Zainab, Rasheed Salman, Nazir Noor Ul Ain, Khan Asif, Rukh Abbas Shah, Wadood Abdul, Rehman Ashfaq Ur

Abstract excerpt

Cyclin-dependent kinase inhibitor 2 A (CDKN2A) gene belongs to the cyclin-dependent kinase family that code for two transcripts (p16INK4A and p14ARF), both work as tumor suppressors proteins. The mutation that occurs in the p14ARF protein can lead to different types of cancers. Single nucleotide polymorphisms (SNPs) are an important type of genetic alteration that can lead to different types of diseases. In this...

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Identifiers

PMID: 35446184
DOI: 10.1080/07391102.2022.2059570

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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