Article

Targeted inhibition of colorectal carcinoma using a designed CEA-binding protein to deliver TCF/LEF transcription factor decoy DNA and p53 protein

2025-06-12

Abstract excerpt

<h4>Summary</h4> Colorectal carcinoma (CRC) is characterized by mutations in Wnt signaling pathway components and the p53 protein, and anti□PD-1/anti□PD-L1 immunotherapy has shown limited efficacy in microsatellite stable CRC patients. In this work, CEABP1, a de novo-designed binding protein for the CRC marker carcinoembryonic antigen (CEA), and cell-penetrating peptide (CPP) were employed for targeted delivery i...

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Literature Corpus work: 8df17bf0-a0ce-5383-875a-b323588b2699
DOI: 10.1101/2025.06.09.658751

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