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Article

The effect of R249S carcinogenic and H168R-R249S suppressor mutations on p53-DNA interaction, a multi scale computational study.

Computers in biology and medicine - 1 May 2010

Rauf Shah Md Abdur, Ismael Mohamed, Sahu Kamlesh Kumar, Suzuki Ai, Koyama Michihisa, Tsuboi Hideyuki, Hatakeyama Nozomu, Endou Akira, Takaba Hiromitsu, Del Carpio Carlos A, Kubo Momoji, Miyamoto Akira

Abstract excerpt

In this study we have undertaken the theoretical analysis of the effect of R249S carcinogenic and H168R-R249S suppressor mutation at core domain of the tumor suppressor protein p53, on its natural interaction with DNA using a newly developed method. The results show that the carcinogenic mutation...

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Identifiers

PMID: 20403587
DOI: 10.1016/j.compbiomed.2010.03.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20403587-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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