Article
Predictive role of microRNA-related genetic polymorphisms in the pathological complete response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer patients.
Oncotarget - 12 Apr 2016
Dreussi Eva, Pucciarelli Salvatore, De Paoli Antonino, Polesel Jerry, Canzonieri Vincenzo, Agostini Marco, Friso Maria Luisa, Belluco Claudio, Buonadonna Angela, Lonardi Sara, Zanusso Chiara, De Mattia Elena, Toffoli Giuseppe, Cecchin Erika
Abstract excerpt
In rectal cancer, a pathologic complete response (pCR) to pre-operative treatment is a favourable prognostic marker, but is reported in a minority of the patients. We aimed at identifying microRNA-related host genetic polymorphisms predictive of pCR. A panel of 114 microRNA-related tagging polymorphisms was selected and analyzed on 265 locally advanced rectal cancer patients treated with neoadjuvant...
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