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Article

Direct binding of microRNA-21 pre-element with Regorafenib: An alternative mechanism for anti-colorectal cancer chemotherapy?

Journal of molecular graphics & modelling - 1 May 2017

Chen Xiaobing, Xie Bojian, Cao Liang, Zhu Feng, Chen Beibei, Lv Huifang, Fan Xingxing, Han Lili, Bie Liangyu, Cao Xinguang, Shen Xiaokun, Cao Feilin

Abstract excerpt

The Regorafenib is a broad-spectrum kinase inhibitor that has been approved to treat colorectal cancer (CRC). However, evidences have shown that the agent is also implicated in drug interaction with microRNA-21 (miR-21), an oncogenic miRNA which plays a key role in resisting programmed cell death in CRC cells. Here, we supposed that, instead of kinase inhibition, Regorafenib can directly bind to and then...

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PMID: 28236743
DOI: 10.1016/j.jmgm.2017.02.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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