Article

PRANA: A Deep Learning Method for Adapting Polygenic Risk Scores to Diverse Ethnic Groups

2026-07-15

Abstract excerpt

Polygenic risk scores (PRSs), which quantify inherited susceptibility to complex traits and diseases, have emerged as valuable tools for risk stratification and precision medicine. Despite their promise, PRS developed on European cohorts often demonstrate substantially reduced predictive accuracy in non-European populations, due to differences in genetic architecture. The disproportionate representation of Europea...

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Literature Corpus work: 78f6cdbc-3e57-5e8d-a3ef-f4216c7ed849
DOI: 10.64898/2026.07.12.26357860

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