Article

A Deep Ensemble Encoder Network Method for Improved Polygenic Risk Score Prediction

2024-08-02

Abstract excerpt

Genome-wide association studies (GWAS) of various heritable human traits and diseases have identified numerous associated single nucleotide polymorphisms (SNPs), most of which have small or modest effects. Polygenic risk scores (PRS) aim to better estimate individuals' genetic predisposition by aggregating the effects of multiple SNPs from GWAS. However, current PRS is designed to capture only simple linear geneti...

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Literature Corpus work: 1acb910b-482b-5024-aea0-7ca92f2290f8
DOI: 10.1101/2024.07.31.24311311

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