Article

Deep Learning for Polygenic Risk Prediction

2024-04-20

Abstract excerpt

Polygenic risk scores (PRS) are relative measures of an individual’s genetic propensity to a particular trait or disease. Most PRS methods assume that mutation effects scale linearly with the number of alleles and are constant across individuals. While these assumptions simplify computation, they increase error, particularly for less-represented racial groups. We developed and provide Delphi (deep learning for phe...

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Literature Corpus work: c9da4cc5-dcdf-59ca-aff5-068d81f60dbb
DOI: 10.1101/2024.04.19.24306079

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