Article

Microglia-derived extracellular vesicles attenuate acute a-synuclein induced astrocyte inflammation

2026-05-12

Abstract excerpt

Aggregates of misfolded α-synuclein (Syn) and neuroinflammation are pathological features of Parkinson’s disease (PD). These, misfolded conformations of Syn promote cytokine and chemokine signaling in the surrounding microenvironment by triggering activation of glial cells through pattern recognition receptors. Microglia and astrocytes act as innate mediators of the neuroimmune response in the brain by regulating...

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Literature Corpus work: 392ef27c-24cf-5ecc-8d01-d42dc92f34fe
DOI: 10.64898/2026.05.11.724371

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