Article

Hypoxia as a key regulator of angiogenesis and inflammation in rheumatoid arthritis : the role of HIF hydroxylases

2014-01-01

Abstract excerpt

Rheumatoid arthritis (RA) is a chronic inflammatory disease with a significant impact on patients' quality of life. One of the well-described features in RA is hypoxia, together with increased infiltration of macrophages into the inflamed joints. Members of the Hypoxia-inducible factor (HIF) family play key roles in activating the transcription of hypoxia regulated genes. Regulation of HIFs, including the enzymes...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 78c3fbfc-69b4-53bf-afc6-9e9893bbcd4a
DOI: 10.25560/33246

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Hypoxia as a key regulator of angiogenesis and inflammation in rheumatoid arthritis : the role of HIF hydroxylasesDOI 10.25560/33246Read

Dissecting out the mechanisms of hypoxia-dependent responses in rheumatoid arthritisSemantic proximity Read

Hypoxia-inducible factor-2α is an essential catabolic regulator of inflammatory rheumatoid arthritis.Semantic proximity Read

The role of hypoxia in inflammatory disease (Review)Semantic proximity Read

The transcriptional response of normal and rheumatoid arthritis synovial fibroblasts to hypoxiaSemantic proximity Read

The Regulation of Macrophage Polarization by Hypoxia-PADI4 Coordination in Rheumatoid ArthritisSemantic proximity Read

Cellular and molecular perspectives in rheumatoid arthritis.Semantic proximity Read

The role of HIF-1alpha in maintaining cartilage homeostasis and during the pathogenesis of osteoarthritis.Semantic proximity Read

[Hypoxia, inflammation and phenotypic plasticity of macrophages: the central role of HIF-1 and NFkappaB].Semantic proximity Read

Functional Repercussions of Hypoxia-Inducible Factor-2α in Idiopathic Pulmonary FibrosisSemantic proximity Read

Hypoxia Promotes a Mixed Inflammatory-Fibrotic Macrophages Phenotype in Active Sarcoidosis.Semantic proximity Read

Hypoxia‐inducible factor‐1 drives divergent immunomodulatory functions in the pathogenesis of autoimmune diseasesSemantic proximity Read

Hypoxia Inducible Factor-1α in Pulmonary Fibrosis: A Promising Therapeutic TargetSemantic proximity Read