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Article

The role of HIF-1alpha in maintaining cartilage homeostasis and during the pathogenesis of osteoarthritis.

1 Jan 2006

Abstract excerpt

As a consequence of the avascular nature of cartilage the microenvironment in which chondrocytes must exist is characterized by hostile conditions, most prominently very low levels of oxygen (hypoxia). In recent years, a vast number of papers reporting on the role of hypoxia in cartilage development and disease has been published. It is well established today that the principal mediator of cellular adaptation to...

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PMID: 16542470
DOI: 10.1186/ar1894

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