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Article

Hypoxia-inducible factor-2α is an essential catabolic regulator of inflammatory rheumatoid arthritis.

PLoS biology - 1 Jun 2014

Ryu Je-Hwang, Chae Chang-Suk, Kwak Ji-Sun, Oh Hwanhee, Shin Youngnim, Huh Yun Hyun, Lee Choong-Gu, Park Yong-Wook, Chun Churl-Hong, Kim Young-Myeong, Im Sin-Hyeog, Chun Jang-Soo

Abstract excerpt

Rheumatoid arthritis (RA) is a systemic autoimmune disorder that manifests as chronic inflammation and joint tissue destruction. However, the etiology and pathogenesis of RA have not been fully elucidated. Here, we explored the role of the hypoxia-inducible factors (HIFs), HIF-1α (encoded by HIF1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24914685
DOI: 10.1371/journal.pbio.1001881
PMCID: PMC4051611

Genes

EPAS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24914685-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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