Article

The Regulation of Macrophage Polarization by Hypoxia-PADI4 Coordination in Rheumatoid Arthritis

2020-11-02

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>: Hypoxia, a common feature of rheumatoid arthritis (RA), induces the overexpression of peptidyl arginine deiminase 4 (PADI4) in fibroblast-like synoviocytes (FLSs) and macrophages. However, the roles of PADI4 and its inducer hypoxia in the regulation of macrophage polarization remain unclear. This study aimed to investigate the role of hypoxia-PADI4 for macrophag...

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Literature Corpus work: 8c18d269-1474-5078-bb8c-52cb203719d2
DOI: 10.21203/rs.3.rs-98320/v1

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