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[Hypoxia, inflammation and phenotypic plasticity of macrophages: the central role of HIF-1 and NFkappaB].

Patologicheskaia fiziologiia i eksperimental'naia terapiia - 1 Jan 2000

Malyshev I Iu, Kruglov S V, Liamina S V

Abstract excerpt

Decrease of oxygen concentration, i.e. hypoxia, in organism tissues and cells is an important pathogenetic component in a large number of diseases. In these cases hypoxia is not only an important component of diseases pathogenesis, but can also influence immune reactions determining the outcome of diseases. Thus, concentration of macrophages in hypoxic areas and their reaction to hypoxia are the key moments in...

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PMID: 23072111

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