Article

Hypoxia Inducible Factor-1α in Pulmonary Fibrosis: A Promising Therapeutic Target

2025-03-15

Abstract excerpt

Pulmonary fibrosis (PF) is a chronic and progressive disease depicted by excessive scarring, which leads to increased tissue stiffness and loss of lung function. The condition is caused by small injuries to the alveolar epithelium, consequential in the formation of fibroblasts, myofibroblasts, and fibroblastic foci areas within the lung tissue. These cells deposit an excessive amount of collagen-rich extracellular...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 400ad7b0-9cc7-5f6a-b3b0-20855ee5020a
DOI: 10.24018/ejmed.2025.7.2.2256

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Hypoxia Inducible Factor-1α in Pulmonary Fibrosis: A Promising Therapeutic TargetDOI 10.24018/ejmed.2025.7.2.2256Read

Functional Repercussions of Hypoxia-Inducible Factor-2α in Idiopathic Pulmonary FibrosisSemantic proximity Read

Hypoxia in Cancer and Fibrosis: Part of the Problem and Part of the SolutionSemantic proximity Read

Hypoxia modulates human pulmonary arterial adventitial fibroblast phenotype through HIF-1α activationSemantic proximity Read

Hypoxia and transforming growth factor β1 regulation of long non‐coding RNA transcriptomes in human pulmonary fibroblastsSemantic proximity Read

Comparative Expression Profiling in Pulmonary Fibrosis Suggests a Role of Hypoxia-inducible Factor-1α in Disease PathogenesisSemantic proximity Read

Hypoxia signaling in human diseases and therapeutic targetsSemantic proximity Read

Hypoxic mast cells accelerate the proliferation, collagen accumulation and phenotypic alteration of human lung fibroblasts.Semantic proximity Read

Hypoxia signaling in human health and diseases: implications and prospects for therapeuticsSemantic proximity Read

Effect of Hypoxia in the Transcriptomic Profile of Lung Fibroblasts from Idiopathic Pulmonary FibrosisSemantic proximity Read

The Hypoxia–Retinoid Axis in Idiopathic Pulmonary Fibrosis: Multifaceted Etiology and Therapeutic PotentialSemantic proximity Read

Hypoxia Inducible Factor 1A Supports a Pro-Fibrotic Phenotype Loop in Idiopathic Pulmonary Fibrosis.Semantic proximity Read

The Effect of Hypoxia-inducible Factor Inhibition on the Phenotype of Fibroblasts in Human and Bovine Pulmonary Hypertension.Semantic proximity Read