Article
Hypoxia Promotes a Mixed Inflammatory-Fibrotic Macrophages Phenotype in Active Sarcoidosis.
Frontiers in immunology - 1 Jan 2021
Jeny Florence, Bernaudin Jean-François, Valeyre Dominique, Kambouchner Marianne, Pretolani Marina, Nunes Hilario, Planès Carole, Besnard Valérie
Abstract excerpt
Background: Macrophages are pivotal cells in sarcoidosis. Monocytes-derived (MD) macrophages have recently been demonstrated to play a major role especially in pulmonary sarcoidosis. From inflammatory tissues to granulomas, they may be exposed to low oxygen tension environments. As hypoxia impact on sarcoidosis immune cells has never been addressed, we designed the present study to investigate MD-macrophages from...
Topics
- Biomarkers
- Case-Control Studies
- Cells, Cultured
- Cytokines
- Disease Susceptibility
- Fibroblasts
- Fibrosis
- Granuloma
- Humans
- Hypoxia
- Hypoxia-Inducible Factor 1, alpha Subunit
- Immunohistochemistry
- Inflammation Mediators