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Article

The transcriptional response of normal and rheumatoid arthritis synovial fibroblasts to hypoxia

16 Sept 2010

Abstract excerpt

OBJECTIVE: Hypoxia is a prominent feature in rheumatoid arthritis (RA) synovium. However, its contribution to the pathogenesis of RA remains unclear. We undertook this study to systematically characterize the changes in gene expression induced by hypoxia in synovial fibroblasts. METHODS: We used microarray expression profiling in paired normoxic and hypoxic cultures of healthy synovial fibroblasts (HSFs) and RA...

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Share to Cancer, Hypoxia, and Metabolism
Share to Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
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PMID: 20848564
DOI: 10.1002/art.27750

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