Article

Serotoninergic Receptor Ligands Improve Tamoxifen Effectiveness on Breast Cancer Cells

2021-02-16

Abstract excerpt

<h4>Background: </h4> The tightly regulated pattern of serotonin (or 5-Hydroxytryptamine, 5-HT) in mammary gland becomes dysregulated in cancer, also contributing to proliferation, metastasis and angiogenesis. Antagonists of serotonin receptors or inhibitors of serotonin reuptake/synthesis may be co-prescribed with Tamoxifen in estrogen receptor-positive (ER + ) tumors, and may modulate its efficacy. Thus, the dis...

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Literature Corpus work: 78aa5e1d-8ec8-5e75-a39c-4a8b04a07348
DOI: 10.21203/rs.3.rs-198756/v1

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