Article

5-HT <sub>2B</sub> serotonin receptor agonist BW723C86 shapes the macrophage gene profile via AhR and impairs monocyte-to-osteoclast differentiation

2019-03-24

Abstract excerpt

<h4>ABSTRACT</h4> Peripheral serotonin (5-HT) exacerbates or limits inflammatory pathologies through interaction with seven types of 5-HT receptors (5-HT 1-7 ). As central regulators of inflammation, macrophages are critical targets of 5-HT, which promotes their anti-inflammatory and pro-fibrotic polarization primarily via the 5-HT 7 -Protein Kinase A (PKA) axis. However, anti-inflammatory human macrophages are...

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Literature Corpus work: 1c4c1553-bd0a-595a-95c7-e051843558ea
DOI: 10.1101/587709

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