Article

Antidepressant Sertraline Hydrochloride Inhibits the Growth of HER2+ AU565 Breast Cancer Cell Line through Induction of Apoptosis, and Arrest of Cell Cycle

2021-09-07

Abstract excerpt

Breast cancer is one the most aggressive cancer worldwide, especially Pakistan due to limited therapeutic options. This study was conducted to repurpose the use of selective serotonin reuptake inhibitors (SSRIs), in the treatment of breast cancers, and merit to pursue drug re-positioning in oncology. Anti-proliferative activity of SSRIs, such as fluoxetine, paroxetine, and sertraline hydrochloride on the growth of...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 068eea46-8b34-56be-b874-d88f4220b9b6
DOI: 10.1101/2021.09.07.459321

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Antidepressant Sertraline Hydrochloride Inhibits the Growth of HER2+ AU565 Breast Cancer Cell Line through Induction of Apoptosis, and Arrest of Cell CycleDOI 10.1101/2021.09.07.459321Read

Alternative Viewpoint Against Breast Cancer Based on Selective Serotonin Receptors 5HTR3A and 5HTR2A Antagonists that can Mediate Apoptosis in MCF-7 Cell LineSemantic proximity Read

Serotoninergic Receptor Ligands Improve Tamoxifen Effectiveness on Breast Cancer CellsSemantic proximity Read

Effect of SSRI exposure on the proliferation rate and glucose uptake in breast and ovary cancer cell linesSemantic proximity Read

Anticancer effects of sanguinarine in triple-negative breast cancer cells via apoptosis induction and cell cycle arrestSemantic proximity Read

Selective serotonin reuptake inhibitors directly signal for apoptosis in biopsy-like Burkitt lymphoma cellsSemantic proximity Read

Artesunate promotes cervical cancer cell apoptosis by regulating Bcl2 family molecules and reducing the mitochondrial membrane potentialSemantic proximity Read

Fluoxetine Modulates Apoptosis and ERK1/2 Phosphorylation in Endometrial Cancer In VitroSemantic proximity Read

Apoptosis Inducing Effect Of Andrographolide On TF-47 Human Breast Cancer Cell LineSemantic proximity Read

Salidroside induces cell-cycle arrest and apoptosis in human breast cancer cellsSemantic proximity Read

The effect of a bis‐structured Schiff base on apoptosis, cytotoxicity, and DNA damage of breast cancer cellsSemantic proximity Read

Effects of Mdm2 Inhibitors on Cellular Viability of Breast Cancer Cell Lines HP100, MCF7Semantic proximity Read

Antioxidant and Apoptotic Effects of an Aqueous Extract of Urtica dioica on the MCF-7 Human Breast Cancer Cell LineSemantic proximity Read