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<i>In vitro</i> ALPK1 kinase assay reveals new insights into ADP-heptose sensing pathway and kinase activity of disease-associated ALPK1 mutants

2023-01-04

Abstract excerpt

<h4>ABSTRACT</h4> Alpha-protein kinase 1 (ALPK1) is a pathogen recognition receptor that detects ADP-heptose (ADPH), a lipopolysaccharide biosynthesis intermediate, recently described as a pathogen-associated molecular pattern in Gram-negative bacteria. ADPH binding to ALPK1 activates its kinase domain and triggers TIFA phosphorylation on threonine 9. This leads to the assembly of large TIFA oligomers called TIFA...

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Literature Corpus work
78a4e56b-e974-54a5-8ab6-24dfa291f2be
DOI
10.1101/2023.01.04.522711
Open publication

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<i>In vitro</i> ALPK1 kinase assay reveals new insights into ADP-heptose sensing pathway and kinase activity of disease-associated ALPK1 mutantsDOI 10.1101/2023.01.04.522711
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