Article
The ALPK1/TIFA/NF-κB axis links a bacterial carcinogen to R-loop-induced replication stress.
Nature communications - 9 Oct 2020
Bauer Michael, Nascakova Zuzana, Mihai Anca-Irina, Cheng Phil F, Levesque Mitchell P, Lampart Simon, Hurwitz Robert, Pfannkuch Lennart, Dobrovolna Jana, Jacobs Melanie, Bartfeld Sina, Dohlman Anders, Shen Xiling, Gall Alevtina A, Salama Nina R, Töpfer Antonia, Weber Achim, Meyer Thomas F, Janscak Pavel, Müller Anne
Abstract excerpt
Exposure of gastric epithelial cells to the bacterial carcinogen Helicobacter pylori causes DNA double strand breaks. Here, we show that H. pylori-induced DNA damage occurs co-transcriptionally in S-phase cells that activate NF-κB signaling upon innate immune recognition of the lipopolysaccharide biosynthetic intermediate β-ADP-heptose by the ALPK1/TIFA signaling pathway. DNA damage depends on the bi-functional...
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