Article

ADP heptose, a novel pathogen-associated molecular pattern associated with <i>Helicobacter pylori</i> type 4 secretion

2018-08-31

Abstract excerpt

The gastric pathogen Helicobacter pylori activates the NF-κB pathway in human epithelial cells via the α-kinase 1 (Alpk1)–TIFA axis. We and others have previously shown that heptose 1,7-bisphosphate (HBP) acts as a pathogen-associated molecular pattern (PAMP). HBP is an intermediate of lipopolysaccharide (LPS) synthesis in H. pylori and other gram-negative bacteria. Deletion of the hldE ( rfaE ) gene encoding...

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Literature Corpus work: 8e00491f-1b54-5e87-9435-3e20ba77959b
DOI: 10.1101/405951

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