Article

Human IRAK kinases differentially alter metabolic regulation and mitochondrial function in <i>Saccharomyces cerevisiae</i>

2025-08-08

Abstract excerpt

<h4>ABSTRACT</h4> Interleukin-1 receptor-associated kinases (IRAKs) are Ser/Thr protein kinases characterized by an N-terminal Death domain (DD). Upon stimulation of Toll-like receptors (TLRs) or the interleukin-1 receptor (IL-1R), IRAKs are recruited to supramolecular signalling complexes, known as myddosomes, through interactions between their DDs and the adaptor protein MyD88. Myddosomes are essential for the...

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Literature Corpus work: f1292101-39ea-589c-97f2-8f4f74c579c4
DOI: 10.1101/2025.08.06.668917

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