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Article

Diseases caused by altered specificity of a protein kinase for its allosteric activators.

Trends in biochemical sciences - 1 Jan 2025

Cohen Philip, Snelling Tom

Abstract excerpt

Protein kinases regulate many intracellular processes, and their dysregulation causes cancers and other diseases. This review focuses on the atypical alpha-kinase 1 (ALPK1), which is activated in mammalian cells by nucleoside diphosphate heptoses (ADP-heptose, UDP-heptose, and CDP-heptose) produced by microbial pathogens but not by mammalian cells. Mutations in human ALPK1 cause ROSAH syndrome and spiradenoma,...

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Identifiers

PMID: 39580356
DOI: 10.1016/j.tibs.2024.10.008

Genes

ALPK1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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