Article

Human Cytomegalovirus UL78 is a Nuclear-Localized GPCR Necessary for Efficient Reactivation from Latent Infection in CD34 <sup>+</sup> Hematopoietic Progenitor Cells

2025-06-02

Abstract excerpt

Human cytomegalovirus (HCMV) is a ubiquitous pathogen that persists throughout the lifetime of the host due in part to the establishment of latency in CD34 + hematopoietic progenitor cells (HPCs) and CD14 + monocytes. HCMV encodes four putative G protein-coupled receptors (GPCRs): US27, US28, UL33, and UL78. While the roles of most of these receptors have been investigated, a definitive role for UL78 in HCMV inf...

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Literature Corpus work: 88af3e24-ba36-57de-8bc0-f937184b5d6b
DOI: 10.1101/2025.06.02.657350

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