Article

Deletion of Glyoxalase 1 exacerbates acetaminophen-induced hepatotoxicity in mice

2023-12-23

Abstract excerpt

<h4>ABSTRACT</h4> Acetaminophen (APAP) overdose triggers a cascade of intracellular oxidative stress events culminating in acute liver injury. The clinically used antidote, N-acetylcysteine (NAC) has a narrow therapeutic window and early treatment is essential for satisfactory therapeutic outcome. For more versatile therapies that can be effective even at late-presentation, the intricacies of APAP-induced hepatot...

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Literature Corpus work: 781333a2-cb76-59af-99dc-37f622304dd3
DOI: 10.1101/2023.12.21.572856

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