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Article

Classically activated mouse macrophages produce methylglyoxal that induces a TLR4- and RAGE-independent proinflammatory response.

Journal of leukocyte biology - 1 Mar 2021

Prantner Daniel, Nallar Shreeram, Richard Katharina, Spiegel David, Collins Kim D, Vogel Stefanie N

Abstract excerpt

The highly reactive compound methylglyoxal (MG) can cause direct damage to cells and tissues by reacting with cellular macromolecules. MG has been identified as a biomarker associated with increased sepsis-induced mortality. Patients undergoing septic shock have significantly elevated circulating MG levels compared to postoperative patients and healthy controls. Furthermore, MG has been implicated in the...

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Identifiers

PMID: 32678947
DOI: 10.1002/JLB.3A0520-745RR
PMCID: PMC7855181

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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