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Article

Hemizygosity of transsulfuration genes confers increased vulnerability against acetaminophen-induced hepatotoxicity in mice.

Toxicology and applied pharmacology - 15 Jan 2015

Hagiya Yoshifumi, Kamata Shotaro, Mitsuoka Saya, Okada Norihiko, Yoshida Saori, Yamamoto Junya, Ohkubo Rika, Abiko Yumi, Yamada Hidenori, Akahoshi Noriyuki, Kasahara Tadashi, Kumagai Yoshito, Ishii Isao

Abstract excerpt

The key mechanism for acetaminophen hepatotoxicity is cytochrome P450 (CYP)-dependent formation of N-acetyl-p-benzoquinone imine, a potent electrophile that forms protein adducts. Previous studies revealed the fundamental role of glutathione, which binds to and detoxifies N-acetyl-p-benzoquinone imine. Glutathione is synthesized from cysteine in the liver, and N-acetylcysteine is used as a sole antidote for...

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Identifiers

PMID: 25499718
DOI: 10.1016/j.taap.2014.11.015

Genes

CBS
CTH
GCLC
GCLM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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