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Article

CD36 deficiency ameliorates drug-induced acute liver injury in mice.

Molecular medicine (Cambridge, Mass.) - 6 Jun 2021

Zhang Chen, Shi Xiao, Su Zhongping, Hu Chao, Mu Xianmin, Pan Jinshun, Li Mengjing, Teng Fengmeng, Ling Tao, Zhao Ting, Xu Che, Ji Guozhong, You Qiang

Abstract excerpt

BACKGROUND: Acetaminophen (APAP) overdose causes hepatotoxicity and even acute liver failure. Recent studies indicate that sterile inflammation and innate immune cells may play important roles in damage-induced hepatocytes regeneration and liver repair. The scavenger receptor CD36 has its crucial functions in sterile inflammation. However, the roles of CD36 in APAP induced acute liver injury remain unclear and...

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Identifiers

PMID: 34092215
DOI: 10.1186/s10020-021-00325-z
PMCID: PMC8182905

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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