Article
Compromised glutathione synthesis results in high susceptibility to acetaminophen hepatotoxicity in acatalasemic mice.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association - 1 Oct 2021
Ogino Noriyoshi, Nagaoka Kenjiro, Tomizuka Kotomi, Matsuura-Harada Yuki, Eitoku Masamitsu, Suganuma Narufumi, Ogino Keiki
Abstract excerpt
Acatalasemia is caused by genetic defect in the catalase gene. Human achatalasemia patients are able to scavenge physiological hydrogen peroxide but are vulnerable to exogenous oxidative stress. In the present study, we used an acetaminophen-induced hepatotoxicity model in acatalasemic mice to explore this vulnerability. Interestingly, the acetaminophen-induced decrease in total glutathione levels was more...
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