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Systems genomics reveals age- and sex-dependent metabolic dysregulation from Glo1 reduction in mice.

Physiological genomics - 1 Mar 2026

Cely Ingrid, Blencowe Montgomery, Shu Le, Diamante Graciel, Ahn In Sook, Zhang Guanglin, LaGuardia Jonnby, Liu Ruoshui, Briscoe Owen, Saleem Zara, Wang Susanna, Davis Richard C, Qi Hongxiu, Lusis Aldons J, Yang Xia

Abstract excerpt

Glyoxalase 1 (Glo1) detoxifies reactive dicarbonyl compounds such as methylglyoxal, a precursor of advanced glycation end products (AGEs), which contribute to metabolic disorders. However, the contribution of AGE-independent mechanisms to Glo1-related metabolic dysfunction remains unclear. We conducted a longitudinal study in male and female Glo1 heterozygous knockdown (Glo1+/-) mice (∼50% Glo1 expression)....

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Identifiers

PMID: 41543389
DOI: 10.1152/physiolgenomics.00106.2025
PMCID: PMC12928164

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