Article

Dysregulation of xenobiotic metabolism and mitochondrial dysfunction exacerbate acetaminophen-induced hepatotoxicity in human antigen R-deficient male mice

2026-01-31

Abstract excerpt

<h4>ABSTRACT</h4> Acetaminophen (APAP) overdose is a leading cause of acute liver failure worldwide. The RNA-binding protein Human antigen R (HuR) is a multifunctional post-transcriptional regulator that plays a pivotal role in cellular stress responses, including those triggered by APAP toxicity. This study investigated the mechanisms by which HuR protects against APAP-induced hepatotoxicity in male mice. Hepato...

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Literature Corpus work: 5f143315-ee1e-5de0-bfe3-c1c7f70cb4ca
DOI: 10.64898/2026.01.28.702297

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