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Article

Glo1 reduction in mice results in age- and sex-dependent metabolic dysfunction

2025-01-25

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objectives</h4> Advanced glycation end products (AGEs) have been implicated as an important mediator of metabolic disorders including obesity, insulin resistance, and coronary artery disease. Glyoxalase 1 (Glo1) is a critical enzyme in the clearance of toxic dicarbonyl such as methylglyoxal, precursors of AGEs. The role of AGE-independent mechanisms that underly Glo1-induced metabolic disor...

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Literature Corpus work
0d494425-83a0-5efa-8b48-d3ffe322170c
DOI
10.1101/2025.01.24.634754
Open publication

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Glo1 reduction in mice results in age- and sex-dependent metabolic dysfunctionDOI 10.1101/2025.01.24.634754
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